Atlantic cod (Gadus morhua) and Atlantic salmon (Salmo salar) immune responses against Aeromonas salmonicida subsp. salmonicida infection

Dávila, Manuel A. Soto (2019) Atlantic cod (Gadus morhua) and Atlantic salmon (Salmo salar) immune responses against Aeromonas salmonicida subsp. salmonicida infection. Masters thesis, Memorial University of Newfoundland.

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Atlantic cod and Atlantic salmon are among the main species of the Canadian fisheries and aquaculture industries. Populations of both fish species are exposed to different pathogens such as bacteria that cause infectious diseases. Vibrio anguillarum, Francisella noatunensis, Renibacterium salmoninarum, and Aeromonas salmonicida subsp. salmonicida are the most frequent bacteria that infect Atlantic cod and Atlantic salmon. Aeromonas salmonicida subsp. salmonicida, is one of the oldest known fish pathogens and the causative agent of furunculosis in marine and freshwater fish. This Gram-negative pathogen is having a negative impact on fish health, especially in emergent marine aquaculture in Canada. A. salmonicida is also an excellent bacterial model to study fish host-pathogen interactions and assist with analyzing compounds that can be useful to stimulate the immunity of the fish. Here, I evaluate the effect of A. salmonicida on the innate immune response of Atlantic cod and Atlantic salmon primary macrophages utilizing microbiological and molecular biology tools. Additionally, I determine the effect of vitamin D₂ and D₃ as potential immunostimulants against the bacterial infection caused by A. salmonicida in Atlantic salmon.

Item Type: Thesis (Masters)
Item ID: 14283
Additional Information: Includes bibliographical references.
Keywords: Atlantic cod, Atlantic salmon, Aeromonas salmonicida, primary macrophages, innate immunity
Department(s): Science, Faculty of > Aquaculture
Science, Faculty of > Ocean Sciences
Date: July 2019
Date Type: Submission
Library of Congress Subject Heading: Aeromonas salmonicida; Atlantic cod--Immunology; Atlantic salmon--Immunology; Ergocalciferol; Cholecalciferol.

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