Modeling the distribution of crossovers and interference with mice DNA data

Shahnaz, Shuhana (2016) Modeling the distribution of crossovers and interference with mice DNA data. Masters thesis, Memorial University of Newfoundland.

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Chiasma and crossover are two related biological processes of great importance in the understanding genetic variation. The study of these processes is straightforward in organisms where all products of meiosis are recovered and can be observed. This is not the case in mammals. Our understanding of these processes depends on our ability to model them. In this study I describe the biological processes that underline chiasma and crossover as well as the two main inference problems associated with these processes: i) in mammals we only recover one of the four products of meiosis and, ii) in general, we do not observe where the crossovers actually happen, but we find an interval containing type-2 censored information. NPML estimate was proposed and used in this work and used to compare chromosome length and chromosome expansion through the crosses.

Item Type: Thesis (Masters)
Item ID: 12160
Additional Information: Includes bibliographical references (pages 73-78).
Keywords: Crossover, Interference, Genetic Distance
Department(s): Science, Faculty of > Mathematics and Statistics
Date: April 2016
Date Type: Submission
Library of Congress Subject Heading: Meiosis; Crossing over (Genetics)--Mathematical models; Nonparametric statistics--Data processing; Quadratic programming

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