Facilitation of lordosis in the female rat by midbrain central gray infusions of substance P

Dornan, Wayne Allan (1984) Facilitation of lordosis in the female rat by midbrain central gray infusions of substance P. Masters thesis, Memorial University of Newfoundland.

[English] PDF (Migrated (PDF/A Conversion) from original format: (application/pdf)) - Accepted Version Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Download (11MB) [English] PDF - Accepted Version Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. (Original Version)

Abstract

Infusions of LHRH ( 50ng ), and Substance P ( 50ng, 500ng, and lug ) into the midbrain central gray led to a prompt facilitation of lordosis which was evident as early as 5 minutes post infusion, and depending on the dose had a duration of at least 120 minutes. Despite an apparent trend, different doses of substance P did not produce a signifcant dose-dependent facilitation of lordosis. Doses of substance P ( 50ng ), and LHRH ( 50ng ), produced effects on lordosis scores, but did not differ between tests. Administration of an anti-serum raised in rabbits against substance P failed to produce a statistically significant reduction in lordosis scores, although here too, a trend was evident.

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