Cinacalcet for Hyperparathyroidism in Pregnancy and Puerperium

Horjus, Carmen and Groot, Inge and Telting, Darryl and van Setten, Petra and van Sorge, Adriaan and Kovacs, Christopher S. and Hermus, Ad and de Boer, Hans (2009) Cinacalcet for Hyperparathyroidism in Pregnancy and Puerperium. Journal of Pediatric Endocrinology & Metabolism, 22 (8). pp. 741-749. ISSN 2191-0251

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The efficacy and safety of various modes of medical treatment for primary hyperparathyroidism (PHPT) in pregnancy is largely unknown. This report describes two cases of PHPT in pregnancy that were temporarily treated with the calcimimetic cinacalcet. The first case was diagnosed in the 31st week of pregnancy. The patient was asymptomatic and had an albumin-corrected total calcium level (Cacorr) of 3.24 mmol/l. As serum calcium was only mildly elevated it was decided to postpone surgery to the postpartum period. Cinacalcet was started immediately after delivery to prevent a postpartum surge in serum calcium. The second patient presented with hypertension and symptomatic hypercalcemia (Cacorr 3.96 mmol/l) in the 32nd week of pregnancy. Surgery was postponed because of suspected pheochromocytoma. Treatment with a combination of cinacalcet and calcitonin reduced serum Cacorr to 3.0 mmol/l. This report describes the monitoring of mother and child, and explores the pros and cons of the use of calcimimetics during pregnancy and puerperium.

Item Type: Article
Item ID: 509
Keywords: Cinacalcet; Hyperparathyroidism; Pregnancy
Department(s): Medicine, Faculty of
Date: August 2009
Date Type: Publication

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