Okagu, Innocent U. (2024) Maternal dietary omega-3 fatty acid intake during gestation influences the fetal brain lipidome and neuronal membrane dynamics. Masters thesis, Memorial University of Newfoundland.
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Abstract
Maternal omega (n)-3 polyunsaturated fatty acid (PUFA) intake during gestation has been shown to promote neurodevelopment and reduce the risk of neuropsychiatric disorders. The goals of this thesis were to investigate the effects of maternal diets differing in n-3 PUFA during gestation on fetal brain lipidomic profiles and neuronal membrane dynamics of C57BL/6 mice. A maternal diet high in n-3 PUFA promoted the accretion of ethanolamine, serine, inositol, and glycerol-based glycerophospholipids (GP), while decreasing the levels of choline-based GP in the fetal brain as gestation progressed, compared with low n-3 PUFA diet. A diet high in n-3 PUFA increased the accretion of docosahexaenoic acid (DHA)-containing GP in the fetal brain as gestation progressed, relative to a diet low in n-3 PUFA. Maternal diets high in n-3 PUFA reduced fetal neuronal membrane thickness and increased area per lipid, suggesting increased membrane fluidity. A high n-3 PUFA diet reduced the cholesteryl ester (CE) flip-flop rate, while increasing the formation of ceramide, CE, and phosphatidylethanolamine-enriched lipid domains in the fetal neuronal membrane, which are associated with improved neurotransmission, memory, and cognition. In summary, the data reported in this thesis suggest that adequate amounts of maternal n-3 PUFA during gestation are necessary for proper fetal brain growth, development, and health.
| Item Type: | Thesis (Masters) |
|---|---|
| URI: | http://research.library.mun.ca/id/eprint/16525 |
| Item ID: | 16525 |
| Additional Information: | Includes bibliographical references (pages 132-188) -- Restricted until June 26, 2025 |
| Keywords: | omega-3 fatty acid, lipidomics molecular dynamic simulation, fetal neuronal membrane, maternal nutrition |
| Department(s): | Science, Faculty of > Biochemistry |
| Date: | April 2024 |
| Date Type: | Submission |
| Library of Congress Subject Heading: | Omega-3 fatty acids; Mothers--Nutrition; Fetal brain; Fetus--Development; Pregnancy--Nutritional aspects; Lipidoses |
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