Differential progression of cognitive and mood-related phenotypes in a mouse model of chronic depression

Corrigan, Mark D. (2023) Differential progression of cognitive and mood-related phenotypes in a mouse model of chronic depression. Masters thesis, Memorial University of Newfoundland.

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Depressive disorders remain highly prevalent and lack effective treatments. Mounting evidence suggests that disrupted cognitive processes, such as uninhibited negative thought patterns (“rumination”), play a significant role in the development of Major Depressive Disorder (MDD), either alongside or preceding serotonin-related mood imbalances. However, the underlying mechanisms of prodromal cognitive symptoms necessitate further investigation. This study explored the differential progression of cognitive and mood-related phenotypes in BALB/c mice subjected to the unpredictable chronic mild stress (UCMS) model. Following two UCMS durations—short-term (2–3 weeks) and long-term (5–6 weeks)—we observed the emergence of distinct symptom sets. Differences in neurobiological processes and substrates were also seen, including alterations to regional metabolic activity. Additionally, sex differences in behavioural measures were identified, in line with previous research pointing to sex-specific vulnerabilities to chronic stress. Altogether, our findings demonstrate the emergence of cognitive deficits associated with dysregulated inhibitory mechanisms in the early stages of depressive-like symptom onset, and may inform the development of preventive treatment strategies.

Item Type: Thesis (Masters)
URI: http://research.library.mun.ca/id/eprint/16141
Item ID: 16141
Additional Information: Includes bibliographical references (pages 41-63)
Keywords: depressive symptom chronology, early depression mouse model, SK3 channels
Department(s): Humanities and Social Sciences, Faculty of > Psychology
Science, Faculty of > Psychology
Date: July 2023
Date Type: Submission
Digital Object Identifier (DOI): https://doi.org/10.48336/21PD-X076
Library of Congress Subject Heading: Depression, Mental--Psychology; Cognitive psychology; Mice--Psychology; Chronic diseases; Phenotype
Medical Subject Heading: Depressive Disorder, Major; Mice; Mice, Inbred BALB C

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