TIGIT Blockade: A Multipronged Approach to Target the HIV Reservoir

Holder, Kayla A. and Grant, Michael D. (2020) TIGIT Blockade: A Multipronged Approach to Target the HIV Reservoir. Frontiers in Cellular and Infection Microbiology, 10 (175). ISSN 2235-2988

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During chronic human immunodeficiency virus type 1 (HIV-1) infection, upregulation of inhibitory molecules contributes to effector cell dysfunction and exhaustion. This, in combination with the ability of HIV-1 to reside dormant in cellular reservoirs and escape immune recognition, makes the pathway to HIV-1 cure particularly challenging. An idealized strategy to achieve HIV-1 cure proposes combined viral and immune activation by “shock”ing HIV-1 out of latency and into an immunologically visible state to be recognized and “kill”ed by immune effector cells. Here we outline the potential for blockade of the inhibitory immune checkpoint T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) to overcome natural killer (NK) cell and T cell inhibition associated with HIV-1 infection and invigorate antiviral effector cell responses against HIV-1 reactivated from the latent cellular reservoir.

Item Type: Article
URI: http://research.library.mun.ca/id/eprint/14782
Item ID: 14782
Additional Information: Memorial University Open Access Author's Fund
Keywords: HIV-1, TIGIT, PVR, checkpoint inhibitor, T cell, NK cell
Department(s): Medicine, Faculty of > Biomedical Sciences
Date: 5 May 2020
Date Type: Publication
Digital Object Identifier (DOI): https://doi.org/10.3389/fcimb.2020.00175
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