Sympathetic nerve response and vascular function: effects of inflammation on nerve-mediated vasoconstriction in the rat tail artery

Fotso Soh, Jocelyn (2016) Sympathetic nerve response and vascular function: effects of inflammation on nerve-mediated vasoconstriction in the rat tail artery. Masters thesis, Memorial University of Newfoundland.

[img] [English] PDF - Accepted Version
Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.

Download (1MB)


Chronic inflammation contributes to changes in vascular function in a range of vascular diseases. Whether these vascular changes in function are nerve-mediated remains unknown. Sympathetic nerve-mediated responses in isolated tail arteries of rats in an experimentally induced chronic inflammatory state were examined. Electrical field stimulations between 1.25 and 40 Hz resulted in frequency-dependent contractions sensitive to tetrodotoxin. Neurogenic contractions in blood vessels of experimental animals were significantly greater compared to those of control animals. Alpha₁-adrenoceptor antagonists significantly inhibited contractile responses at lower frequencies of stimulation (1.25 – 5 Hz) in blood vessels of experimental rats compared to controls. Alpha₂-adrenoceptor antagonism had no effect on electric field-evoked vasoconstrictions in experimental and control animals. Inhibition of neuronal reuptake by cocaine comparably enhanced field-stimulated responses in blood vessels of experimental and control animals. Furthermore, the expression of α₁- and α₂-adrenoceptors was different in the endothelium of blood vessels of treated animals compared to control animals. The observation of enhanced neurogenic contraction in blood vessels of animals in a chronic state of inflammation may be attributed to alterations in responsiveness and/or distribution of postjunctional α₁-adrenoceptors.

Item Type: Thesis (Masters)
Item ID: 12147
Additional Information: Includes bibliographical references (pages 85-103).
Keywords: Sympathetic nerves, Vascular function, Inflammation, Rat tail artery
Department(s): Medicine, Faculty of > Biomedical Sciences
Date: May 2016
Date Type: Submission
Library of Congress Subject Heading: Inflammation--Mediators; Arteritis--Animal models; Vasoconstrictors; Rats as laboratory animals
Medical Subject Heading: Inflammation Mediators; Arteritis; Vasconstriction; Disease Models, Animal; Rats

Actions (login required)

View Item View Item


Downloads per month over the past year

View more statistics