Scope & nature of young sudden cardiac death in Newfoundland & Labrador

Hamilton, Gina (2016) Scope & nature of young sudden cardiac death in Newfoundland & Labrador. Masters thesis, Memorial University of Newfoundland.

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Introduction: Sudden cardiac death (SCD) in young people (ages 2-40) is a tragedy for families and communities alike. It has multiple causes, one of which is an underlying genetic arrhythmogenic cardiomyopathy. A study from Ontario (ON) using a 2008 cohort assessed the incidence of SCD in persons aged 2-40 years to be 2.64/100,000 person-years. We hypothesized that Newfoundland & Labrador (NL) may have a higher incidence of early SCD in ages 2-40 due to possible underlying genetic causes given the historical genetic isolation of the population and the founder mutations already identified (ex. PKP2, RYR2, TMEM43). Methods: We ascertained cases of sudden death from the comprehensive Medical Examiners’ provincial database for the years 2008 and 1997; 2008 as a direct comparison to ON, and 1997 as it represented a time when the implantable cardioverter-defibrillator was not available in NL. Each case of sudden death was individually analyzed to determine likelihood of SCD. Results: There were 119 cases in 2008 and 157 cases in 1997. The incidence of SCD for ages 2-40 in 2008 was 7.32/100,000 persons. This was significantly higher than the incidence in Ontario. The incidence of SCD was not significantly higher in 1997 than 2008. Coronary artery disease was a major cause of death in all cohorts, similar to Ontario (non-significant difference). Conclusion: In general, there was a trend of more arrhythmogenic deaths in the young and more structural cardiac deaths as age increased. This reflects the cause of SCD in the young is often genetic in nature, while older deaths are often due to coronary artery disease, a disease heavily influenced by environment. To conclude, SCD in NL occurs at a higher incidence than ON, further research is needed on the topic.

Item Type: Thesis (Masters)
Item ID: 11754
Additional Information: Includes bibliographical references (pages 63-69).
Keywords: Sudden cardiac death, Genetics, Autopsy
Department(s): Medicine, Faculty of
Date: May 2016
Date Type: Submission
Geographic Location: Newfoundland and Labrador
Library of Congress Subject Heading: Cardiac arrest--Newfoundland and Labrador--Genetic aspects; Cardiac arrest in children--Newfoundland and Labrador--Genetic aspects; Cardiac arrest--Newfoundland and Labrador--Etiology; Myocardium--Diseases
Medical Subject Heading: Heart Arrest--genetics--Newfoundland and Labrador; Heart Arrest--etiology--Newfoundland and Labrador; Heart Diseases; Child, Preschool, Child, Adolescent; Adult

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