Sleep quality, depression, and quality of life in patients with chronic kidney disease: a single centre experience

Sekercioglu, Nigar (2014) Sleep quality, depression, and quality of life in patients with chronic kidney disease: a single centre experience. Masters thesis, Memorial University of Newfoundland.

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Abstract

Background: Sleeping problems and depression are more common in patients with chronic kidney disease (CKD) than the general population. The primary objective of this cross-sectional study was to test factors associated with sleep disturbances, depression, and quality of life among patients with CKD. Methods: We recruited patients with CKD who lived in the St. John’s area from September 2012 to December 2012. The Pittsburgh Sleep Quality Index (PSQI), the Berlin Questionnaire (BQ), the Beck Depression Inventory (BDI), the Beck Depression Inventory Fast-Screen for Medical Patients (BDI-FS), and the Short Form 36 Quality of Life Health Survey Questions (SF-36) were administered to all participants. A chart review was performed for the patients’ demographics, diagnoses, medication lists, and certain laboratory parameters—including blood glucose, hemoglobin, albumin, calcium, phosphate, parathyroid hormone, and estimated glomerular filtration rate (e-GFR). Logistic regression models were employed to estimate odds ratios (OR) with 95% confidence intervals (CI). Results: The sample had a total of 303 patients (41% female and 99% Caucasian). One hundred and seventeen (39%) patients were labeled as poor sleepers with the PSQI, while 157 (51.8%) patients had high risk for sleep apnea in the study cohort. Physical component scores (PCS) and mental component scores (MCS) of the SF-36 questionnaire were significantly lower in the dialysis group when compared to the non-dialysis group. iii A higher risk for impaired sleep was associated with being a female and on antidepressants and/or benzodiazepine or non-benzodiazepine hypnotic agents. Conclusions: Sleep problems and depression are common in kidney patients. Women are more prone to sleeping problems than their male counter-parts. Furthermore, people who have low MCS scores are more prone to impaired sleep or vice versa.

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