A propensity score matched analysis of long-term mortality outcomes in patients aged 50 to 70 years after isolated mechanical versus bioprosthetic aortic valve replacement in Newfoundland and Labrador

Buckley, Alvan (2020) A propensity score matched analysis of long-term mortality outcomes in patients aged 50 to 70 years after isolated mechanical versus bioprosthetic aortic valve replacement in Newfoundland and Labrador. Masters thesis, Memorial University of Newfoundland.

[English] PDF - Accepted Version Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Download (1MB)

Abstract

OBJECTIVE: Compare long-term mortality of patients after mechanical versus bioprosthetic aortic valve replacement in Newfoundland and Labrador METHODS: Retrospective cohort analysis of patients aged 50 to 70 years who underwent aortic valve replacement in Newfoundland and Labrador between 2006 and 2014. A logistic regression propensity score generated a subset of 52 matched patients. The long-term outcome of survival was assessed. RESULTS: Of 189 patients included, 135 (71%) received mechanical valves, while 54 (29%) received bioprosthetic valves. The mean age in the matched group was 63 (mechanical) and 64 years (bioprosthetic) (P = 0.64). Mean follow-up was 8.1 (maximum 13.8) years. Survival at 30 days, 1, 5, and 10 years was: 100%, 96%, 85%, and 81% (mechanical) versus 100%, 96%, 89%, and 67% (bioprosthetic). The hazard ratio for mortality between mechanical and bioprosthetic valves was 0.64 (95% CI 0.18-2.3, P = 0.491). Secondary outcomes revealed that the most common cause of death to be cardiovascular in etiology (39%), followed by malignancies (27%). CONCLUSIONS: We found no statistically significant difference in long-term survival in patients aged 50 to 70 years after mechanical versus bioprosthetic aortic valve replacement.

Actions (login required)

View Item