Effects of traffic related air pollution exposure on childhood asthma onset during the different developmental stages of childhood

Lau, Nelson (2020) Effects of traffic related air pollution exposure on childhood asthma onset during the different developmental stages of childhood. Masters thesis, Memorial University of Newfoundland.

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Abstract

Childhood asthma is a chronic condition which affects millions of children worldwide. It is associated with many risk factors, including traffic related air pollution (TRAP). While the relationship between TRAP and childhood asthma is well established, the relationship between TRAP and different childhood asthma patterns, or phenotypes is less well studied. This thesis consists of a systematic review and an analysis of a longitudinal cohort study addressing this knowledge gap. The results from our systematic review suggest that TRAP is associated most strongly in early childhood asthma phenotypes, which is supported by the results of our longitudinal cohort study (Quartile 3 OR: 2.11, 95% CI: 1.29, 3.44, Quartile 4 OR: 2.16, 95% CI: 1.27, 3.68 compared to Quartile 1 of NO₂ exposure for early childhood onset asthma phenotype). Our results suggest that younger children are more susceptible to TRAP compared to older children and emphasize the importance of considering asthma phenotypes in future research.

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