The relationship between body mass index and coronary artery disease in Newfoundland and Labrador, Canada

Gregory, Anne Bernadette (2017) The relationship between body mass index and coronary artery disease in Newfoundland and Labrador, Canada. Masters thesis, Memorial University of Newfoundland.

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Abstract

The focus of this master’s research was two-fold. First, the relationship between body mass index (BMI) and severity of coronary artery disease (CAD) was examined in patients undergoing diagnostic coronary angiography (CA) for suspected CAD in Newfoundland and Labrador, Canada. The primary outcomes were 1-year all-cause and cardiac specific mortality. Second, in patients with established CAD and undergoing percutaneous coronary intervention (PCI) the relationship between BMI and short-term adverse events including vascular and non-vascular (i.e., in-lab and post-procedural) complications was investigated. This thesis is presented in manuscript form and consists of four chapters with the first being an introduction and the fourth, final chapter being a discussion. The second chapter focuses on the relationship between BMI and angiographic severity of CAD, while the third chapter focuses on the impact of BMI on vascular and non-vascular complications in patients undergoing PCI. This research failed to detect an association of BMI levels with 1-year mortality in patients with suspected CAD after adjustment for potential confounding variables. Further, overweight and obesity were not independent correlates of short-term complications among patients with established CAD who had a PCI.

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