Salt sensitivity in C57 and eNOS knockout mice

Leonard, Allison M. (2005) Salt sensitivity in C57 and eNOS knockout mice. Masters thesis, Memorial University of Newfoundland.

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Abstract

Objectives: The present study examined the basal blood pressure (BP) and salt sensitivity of endothelial nitric oxide synthase (eNOS) knockout (KO) mice and their control strain (C57) mice. -- Methods: Mice, age 12-18 wks, were fed a regular (0.7o/o NaCl) or a high (8% NaCl) salt diet for 6 weeks. BP, heart rate, pulse pressure and activity levels were recorded by telemetry. Results were calculated for the 12h light, 12h dark and total24h periods. Results: eNOS-KO mice exhibited an augmented basal BP and a heightened level of BP salt sensitivity. C57 mice displayed a slight degree of BP salt sensitivity. The effects of salt were more pronounced in the dark phase of the day perhaps reflecting the nocturnal nature of mice. -- Conclusion: eNOS-KO mice have a higher basal BP and BP salt sensitivity than the control strain.

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