Xia, Yue (2024) Neuronal activity in the basolateral amygdala following olfactory threat conditioning, extinction and second order conditioning. Masters thesis, Memorial University of Newfoundland.
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Abstract
This thesis investigates the neuronal activities within the basolateral amygdala (BLA) in response to olfactory threat conditioning, extinction and second order conditioning. With a focus on neuronal representation underlying memory processing, I employed advanced techniques such as viral transduction, immunofluorescence and immunohistochemistry in both young and aged Sprague-Dawley rats. Results demonstrate that the BLA is critical in olfactory threat memory acquisition and extinction in animal models. Furthermore, the study reveals age-related differences in extinction learning, suggesting alterations in NMDAR function and amygdala activity with aging. Using a tTA-c-Fos/TRE-GFP double transgene approach, I showed that sensory cues involved in second order conditioning merged their representations in the BLA. These findings give us a deeper understanding of the neural basis of odor threat conditioning, extinction and higher order learning, offering potential insights for addressing anxiety-related disorders and the impact of aging on cognitive functions.
| Item Type: | Thesis (Masters) |
|---|---|
| URI: | http://research.library.mun.ca/id/eprint/16532 |
| Item ID: | 16532 |
| Additional Information: | Includes bibliographical references (pages 45-65)--Restricted until September 30, 2025 |
| Keywords: | BLA, learning, cFos, extinction, threat conditioning |
| Department(s): | Medicine, Faculty of > Biomedical Sciences |
| Date: | October 2024 |
| Date Type: | Submission |
| Medical Subject Heading: | Basolateral Nuclear Complex; Amygdala; Immunohistochemistry; Rats; Olfactory Pathways |
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