The self-controlled case series design: a simulation study

Cai, Kaida (2015) The self-controlled case series design: a simulation study. Masters thesis, Memorial University of Newfoundland.

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Abstract

The self-controlled case series (SCCS) design is an outcome dependent sampling design developed to investigate the association between time-varying exposures and outcome events. This design automatically adjusts for all fixed covariates acting multiplicatively on the intensity function of a subject. It is based only on cases, and ignores controls. Since only cases are included, it is economically and computationally efficient compared with a cohort design. This property of the SCCS design also helps protecting data privacy. Because of these reasons, the SCCS design is an important alternative to the cohort design especially when the outcome of interest is a rare event, and has been used in many studies in medicine, epidemiology and pharmacoepidemiology. Therefore, the main objective of this thesis is to investigate the SCCS design through simulations. We considered parametric, semiparametric and weakly parametric SCCS models, and compared them with well-known models based on the classical cohort design. We also illustarted the methods with a real life data set from medicine.

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