An examination of the hypothesis that structural changes which occur in hypertension, are a result of the increase in arterial pressure

Pang, Stephen Ching-ng (1982) An examination of the hypothesis that structural changes which occur in hypertension, are a result of the increase in arterial pressure. Doctoral (PhD) thesis, Memorial University of Newfoundland.

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Abstract

The hypothesis that the medial hypertrophy which occurs in jejunal arteries of the SHR during development is a result of elevation of arterial pressure, was examined. The morphological changes occurring in the jejunal arteries of SHR and normotensive WKY during development were compared with those occurring in jejunal arteries transplanted between the two strains, in WKY in which the blood pressure had been elevated by renal artery constriction and in SHR which had been rendered normotensive by capsaicin treatment. Although it is still premature to draw the final conclusion on the causes of medial hypertrophy is neither the result of inherent generic factors in the arterial wall, nor the increase in arterial pressure, but due to some other factors such as innervation of the arteries or circulating hormones in the blood.

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