Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease

Williams, Christopher E. (2015) Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease. Masters thesis, Memorial University of Newfoundland.

[img] [English] PDF - Accepted Version
Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.

Download (618Kb)

Abstract

Background & Objectives: Quality of life (QOL) is impaired in end-stage renal disease patients, but the cause(s) is uncertain. To determine whether biomarkers of cardiac disease (TNT, NT-proBNP) were associated with change in QOL in the short (24 weeks) and long term (48 & 96 weeks) we studied 596 new hemodialysis patients without symptomatic cardiac disease followed for 2 years. Design, Setting, Participants & Measurements: Patients were enrolled in a doubleblind, randomized controlled trial to assess the impact of anemia correction with erythropoietin. Change in QOL was measured using SF-36, FACIT Fatigue administered at 0, 24, 48 and 96 weeks, with pre-specified domains of interest being SF-36 Physical Functioning, SF-36 Vitality and FACIT Fatigue. In addition to baseline demographic and clinical characteristics, baseline biomarkers of cardiac disease and inflammation were assessed. Results: The analysis plan pre-specified cut-off for baseline biomarkers as upper quartile. High Trop levels were independently and significantly associated with long term deterioration in all 3 domains. The adjusted B for change in physical function was -6.7 (p=0. 035) at 48 weeks and -7.1(p=0.056) at 96 weeks; for change in vitality - 7.1(p=0.036) at 96 weeks; and for change in fatigue-6.2(p=0.035). Conclusions: In relatively healthy hemodialysis patients, high troponin T levels were associated with deterioration in physical function and vitality as well as increasing fatigue.

Item Type: Thesis (Masters)
URI: http://research.library.mun.ca/id/eprint/8442
Item ID: 8442
Additional Information: Includes bibliographical references (pages 56-60).
Keywords: Quality of Life, End stage renal disease, Troponin T, Cardiac disease, BNP, Hemodialysis
Department(s): Medicine, Faculty of
Date: May 2015
Date Type: Submission
Library of Congress Subject Heading: Chronic renal failure--Patients--Health and hygiene; Health status indicators; Biochemical markers--Diagnostic use; Heart--Examination
Medical Subject Heading: Kidney Failure, Chronic; Renal Dialysis; Health Status Indicators; Biological Markers

Actions (login required)

View Item View Item

Downloads

Downloads per month over the past year

View more statistics