McKnight, Leslie Louise (2008) The effects of fetal and post-natal growth rates on the development of type 2 diabetes in Yucatan miniature pigs. Masters thesis, Memorial University of Newfoundland.
- Accepted Version
Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
Epidemiological studies have linked small birth weight and rapid compensatory growth to a number of chronic diseases, such as type 2 diabetes, hypertension and cardiovascular disease (Chapter 1). Despite their many uses in biomedical research, few studies have used swine as a model for fetal programming. The overall goal of this research was to develop a Yucatan miniature pig model of fetal programming. Specifically we wanted to determine the effects of birth weight, postnatal growth rate and early postnatal nutrition on the development of type 2 diabetes in Yucatan miniature swine (Chapter 2). In order to do so, we needed to demonstrate compensatory growth (Chapter 3) and validate the miniature pig as a model for type 2 diabetes (Chapter 4). Although runt pigs displayed compensatory growth, growth characteristics were not related to any markers of type 2 diabetes development (Chapter 5).
|Item Type:||Thesis (Masters)|
|Additional Information:||Includes bibliographical references (leaves 94-104).|
|Keywords:||Yucatan, miniature pig, compensatory growth, type 2 diabetes, fetal programmmg|
|Department(s):||Science, Faculty of > Biochemistry|
|Library of Congress Subject Heading:||Miniature pigs--Growth; Non-insulin-dependent diabetes--Epidemiology.|
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