Molecular correlates of multiday memory in an appetitive conditioning model: insights into mediators of memory extension

Strong, Vanessa Dawn (2014) Molecular correlates of multiday memory in an appetitive conditioning model: insights into mediators of memory extension. Masters thesis, Memorial University of Newfoundland.

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    Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
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Abstract

These experiments provide insight into potential mediators implicated in the maintenance of memory duration using an olfactory preference learning paradigm. Neonatal rats were trained in a single training session by pairing odor (CS) with pharmacological agents (UCS) to promote odor preference of different durations (24h, 4-Day and 5-Day). For the first time in olfactory preference learning we characterize the pCREB expression profile as biphasic with peaks at 10min and 2h post-conditioning in 24h and 5-Day olfactory preference memory. Second, we show histone acetylation is enhanced by HDAC inhibition via NaB in both learning and non-learning conditions. Finally, q-PCR reveals CREB target genes Nr4a1 and Egr-1 are differentially expressed across 24h and 5-Day models, consistent with a possible role in memory extension. These experiments support CREB as a possible initiator in mediating downstream events leading to the changes in synaptic plasticity that accompany extension of long-term memory.

Item Type: Thesis (Masters)
URI: http://research.library.mun.ca/id/eprint/6448
Item ID: 6448
Additional Information: Includes bibliographical references (pages 77-90).
Department(s): Medicine, Faculty of
Date: May 2014
Date Type: Submission

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