A randomized trial of efficacy and safety of adjunctive vitamin D in the treatment of active tuberculosis in India

Daley, Peter (2014) A randomized trial of efficacy and safety of adjunctive vitamin D in the treatment of active tuberculosis in India. Masters thesis, Memoral University of Newfoundland.

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Abstract

Background: Vitamin D supplementation may benefit patients with active tuberculosis (TB) Design: A randomized, double-blinded, placebo-controlled clinical trial comparing standard active TB treatment to active TB treatment plus supplemental high dose oral vitamin D3 was performed in India. Methods: Treatment naïve, smear positive, HIV negative, pulmonary TB patients were randomized into two equal groups. Results: 247 patients were randomized, 121 to vitamin D and 126 to placebo. Baseline characteristics in both groups were similar. 101 patients in the vitamin D arm and 110 patients in the placebo arm were analyzed. Median time to culture conversion in the vitamin D group was 43.0 days (95% C.I. = 33.3 to 52.8), as compared to was 42.0 days (33.9 to 50.1) in the placebo group (p=0.95 by log rank test). Hypercalcemia was not observed. Conclusions: Vitamin D supplementation was safe but did not influence time to culture conversion.

Item Type: Thesis (Masters)
URI: http://research.library.mun.ca/id/eprint/6291
Item ID: 6291
Additional Information: Includes bibliographical references.
Department(s): Medicine, Faculty of
Date: May 2014
Date Type: Submission
Geographic Location: India
Library of Congress Subject Heading: Tuberculosis--Nutritional aspects; Vitamin D in human nutrition-India; Dietary supplements--Physiological effect--India; Tuberculosis--Diet therapy--India

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