Controlled cell proliferation on an electrochemically engineered collagen scaffold

Poduska, Kristin M. and Gendron, Robert L. and Kumar, M. Ramesh and Paradis, Helene and Martin, Darryl and Ho, Nhu and Gardiner, Danielle and Merschrod S., Erika F. (2012) Controlled cell proliferation on an electrochemically engineered collagen scaffold. Macromolecular Bioscience, 12 (3). pp. 360-366. ISSN 1616-5195

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Abstract

Therapies for corneal disease and injury often rely on artificial implants, but integrating cells into synthetic corneal materials remains a significant challenge. The electrochemically formed collagen-based matrix presented here is non-toxic to cells and controls the proliferation in the corneal fibroblasts seeded onto it. Histology and biomolecular studies show a behavior similar to corneal stromal cells in a native corneal environment. Not only is this result an important first step toward developing a more realistic, multi-component artificial cornea, but it also opens possibilities for using this matrix to control and contain the growth of cells in engineered tissues.

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