The clinical biochemistry of chicks with aflatoxicosis : some effects of supplementary choline, folate, threonine, lysine and lysine plus arginine

Park, Laura (1983) The clinical biochemistry of chicks with aflatoxicosis : some effects of supplementary choline, folate, threonine, lysine and lysine plus arginine. Masters thesis, Memorial University of Newfoundland.

[img] [English] PDF (Migrated (PDF/A Conversion) from original format: (application/pdf)) - Accepted Version
Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.

Download (21Mb)
  • [img] [English] PDF - Accepted Version
    Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
    (Original Version)

Abstract

Aflatoxin (2.5ug/g diet) was fed to broiler chicks for 24-26 days in five separate feeding trials in which the effects of supplementary choline, folate, threonine, lysine, and lysine plus arginine were examined. Weight gain, feed intake, feed conversion, and hepatic lipid responded in a manner typical for aflatoxicosis. Plasma concentrations of LDH, taurine, tyrosine, phenylalanine, arginine, ornithine, citrulline, glutamine, ammonia and perhaps BUN were increased in response to aflatoxin, while plasma levels of threonine, lysine, total protein, albumin/globulin (A/G) ratio, uric acid, cholesterol, calcium, inorganic phosphate, total iron, total iron binding capacity, and percent saturated transferrin, decreased. -- Intraperitoneal (IP) administration of choline, but not dietary choline, moderated the influence of aflatoxin on the majority of the biochemical parameters. -- Lysine supplementation improved the performance of chicks with aflatoxicosis, while threonine had a negative effect. This may be related to ornithine detoxification of aflatoxin through the opposing effects of these two amino acids on the activity of the enzyme arginase, which catalyzes the conversion of arginine to ornithine and urea. -- Plasma lysine concentration varies considerably as a result of genetic differences in lysine metabolism. Data indicates that chicks with high plasma lysine concentration are more resistant to aflatoxicosis than chicks with low plasma concentrations of lysine.

Item Type: Thesis (Masters)
URI: http://research.library.mun.ca/id/eprint/4030
Item ID: 4030
Additional Information: Bibliography: leaves 77-84.
Department(s): Science, Faculty of > Biochemistry
Date: 1983
Date Type: Submission
Library of Congress Subject Heading: Chicks--Diseases; Aflatoxins

Actions (login required)

View Item View Item

Downloads

Downloads per month over the past year

View more statistics