Case, Michael and Treuer, Tamas and Karagianis, Jamie and Hoffmann, Vicki P. (2010) The potential role of appetite in predicting weight changes during treatment with olanzapine. BMC Psychiatry, 10 (72). pp. 1-9. ISSN 1471-244X
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Background Clinically significant weight gain has been reported during treatment with atypical antipsychotics. It has been suggested that weight changes in patients treated with olanzapine may be associated with increased appetite. Methods Data were used from adult patients for whom both appetite and weight data were available from 4 prospective, 12- to 24-week clinical trials. Patients' appetites were assessed with Eating Behavior Assessment (EBA, Study 1), Platypus Appetite Rating Scale (PARS, Study 2), Eating Inventory (EI, Study 3), Food Craving Inventory (FCI, Study 3), and Eating Attitude Scale (EAS, Study 4). Results In Studies 1 (EBA) and 4 (EAS), patients who reported overall score increases on appetite scales, indicating an increase in appetite, experienced the greatest overall weight gains. However, in Studies 2 (PARS) and 3 (EI, FCI), patients who reported overall score increases on appetite scales did not experience greater weight changes than patients not reporting score increases. Early weight changes (2-4 weeks) were more positively correlated with overall weight changes than early or overall score changes on any utilized appetite assessment scale. No additional information was gained by adding early appetite change to early weight change in correlation to overall weight change. Conclusions Early weight changes may be a more useful predictor for long-term weight changes than early score changes on appetite assessment scales.
|Keywords:||adult; aged; appetite; article; bipolar disorder; clinical assessment; clinical study; controlled study; decreased appetite; drug use; eating habit; female; food preference; human; increased appetite; major clinical study; male; patient assessment; prediction; prospective study; psychological rating scale; psychosis; schizoaffective psychosis; schizophrenia; weight change; weight gain; olanzipine|
|Date:||14 September 2010|
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