Special considerations in prognostic research in cancer involving genetic polymorphisms

Savas, Sevtap and Liu, Geoffrey and Xu, Wai (2013) Special considerations in prognostic research in cancer involving genetic polymorphisms. BMC Medicine, 11 (149). ISSN 1741-7015 (In Press)

[img] [English] PDF (Migrated (PDF/A Conversion) from original format: (application/pdf)) - Accepted Version
Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.

Download (698Kb)
  • [img] [English] PDF - Accepted Version
    Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
    (Original Version)

Abstract

Analysis of genetic polymorphisms may help identify putative prognostic markers and determine the biological basis of variable prognosis in patients. However, in contrast to other variables commonly used in the prognostic studies, there are special considerations when studying genetic polymorphisms. For example, variable inheritance patterns (recessive, dominant, codominant, and additive genetic models) need to be explored to identify the specific genotypes associated with the outcome. In addition, several characteristics of genetic polymorphisms, such as their minor allele frequency and linkage disequilibrium among multiple polymorphisms, and the population substructure of the cohort investigated need to be accounted for in the analyses. In addition, in cancer research due to the genomic differences between the tumor and non-tumor DNA, differences in the genetic information obtained using these tissues need to be carefully assessed in prognostic studies. In this article, we review these and other considerations specific to genetic polymorphism by focusing on genetic prognostic studies in cancer.

Item Type: Article
URI: http://research.library.mun.ca/id/eprint/1979
Item ID: 1979
Additional Information: Memorial University Open Access Author's Fund
Department(s): Medicine, Faculty of
Date: 17 June 2013
Date Type: Publication
Related URLs:

Actions (login required)

View Item View Item

Downloads

Downloads per month over the past year

View more statistics