Cerebrovascular dysfunction in the presence of chronic inflammation

Randell, Amy (2016) Cerebrovascular dysfunction in the presence of chronic inflammation. Masters thesis, Memorial University of Newfoundland.

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Abstract

Background: Patients with autoimmune disease have increased incidence of stroke. Hemorrhagic stroke (HS) is associated with loss of cerebrovascular function, leading to micro-vessel burst, and hemorrhage. We believe chronic inflammation is involved in loss of cerebrovascular function and HS. We established a hypertensive-arthritis model in spontaneously hypertensive rats (SHR) fed either standard rodent diet (0.59% NaCl) (RD) or high salt diet (4% NaCl) (HSD) and compared them to non-inflamed SHR. Methods: Complete Freund’s adjuvant (CFA) was injected into the left paw to induce mono-arthritis. Blood pressure and inflammation was monitored. At endpoint, animals were sacrificed and evaluated for HS while middle cerebral artery (MCA) was isolated for functional studies. Results: HS was observed in 90% of CFA-treated groups. The MCA of arthritic RD-SHR exhibited decreased ability to undergo pressure dependent constriction (PDC). All HSD-SHR showed a decreased response to PDC. However, arthritic HSD-SHR also demonstrated a diminished response to vasoactive peptides. Conclusion: HS occurring with CFA injection corresponds with loss of MCA function. Chronic HSD appears to further exacerbate vascular dysfunction in the MCA.

Item Type: Thesis (Masters)
URI: http://research.library.mun.ca/id/eprint/12035
Item ID: 12035
Additional Information: Includes bibliographical references (pages 113-129).
Keywords: pressure dependent constriction, rheumatoid arthritis, hypertension, spontaneously hypertensive rat, high salt diet, hemorrhagic stroke, animal model, complete freund's adjuvant, mono-arthritis, adjuvant-induced arthritis, interleukin-17a
Department(s): Pharmacy, School of
Date: April 2016
Date Type: Submission
Library of Congress Subject Heading: Cerebrovascular disease--Animal models; Cerebrovascular disease--Pathophysiology; Inflammation; Autoimmunity
Medical Subject Heading: Cerebrovascular Disorders; Cerebrovascular Disorders--physiopathology; Models, Animal; Inflammation; Autoimmunity

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