Khalili, Sammy (2012) Nutritional regulation of adiponectin and the effect of genetic variations in the adiponectin gene on bone density in the Newfoundland population. Masters thesis, Memorial University of Newfoundland.
- Accepted Version
Available under License - The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
Adiponectin, as an adipokine, has been shown to be involved in insulin sensitivity and obesity. Recently data mainly from animal models, have suggested that adiponectin may have a role in bone metabolism. This project addresses the association of adiponectin with insulin sensitivity and obesity status, the regulation of positive energy challenge on adiponectin, and the association of DNA sequence variation in adiponectin gene with bone mineral density in the Newfoundland population. This project comprises two studies: I) a Newfoundland-population based-genetic-association cohort study and 2) an overfeeding study.
|Item Type:||Thesis (Masters)|
|Additional Information:||Includes bibliographical references (leaves 149-167).|
|Department(s):||Medicine, Faculty of|
|Library of Congress Subject Heading:||Cytokines--Physiological effect--Newfoundland and Labrador; Bones--Metabolism--Endocrine aspects; Bones--Density; Genetic regulation.|
|Medical Subject Heading:||; Adiponectin; Bone Density; Genetic Association Studies.|
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