Nutritional regulation of adiponectin and the effect of genetic variations in the adiponectin gene on bone density in the Newfoundland population

Khalili, Sammy (2012) Nutritional regulation of adiponectin and the effect of genetic variations in the adiponectin gene on bone density in the Newfoundland population. Masters thesis, Memorial University of Newfoundland.

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Abstract

Adiponectin, as an adipokine, has been shown to be involved in insulin sensitivity and obesity. Recently data mainly from animal models, have suggested that adiponectin may have a role in bone metabolism. This project addresses the association of adiponectin with insulin sensitivity and obesity status, the regulation of positive energy challenge on adiponectin, and the association of DNA sequence variation in adiponectin gene with bone mineral density in the Newfoundland population. This project comprises two studies: I) a Newfoundland-population based-genetic-association cohort study and 2) an overfeeding study.

Item Type: Thesis (Masters)
URI: http://research.library.mun.ca/id/eprint/10797
Item ID: 10797
Additional Information: Includes bibliographical references (leaves 149-167).
Department(s): Medicine, Faculty of
Date: 2012
Date Type: Submission
Library of Congress Subject Heading: Cytokines--Physiological effect--Newfoundland and Labrador; Bones--Metabolism--Endocrine aspects; Bones--Density; Genetic regulation.
Medical Subject Heading: ; Adiponectin; Bone Density; Genetic Association Studies.

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